Available data has indicated an increasing trend of dengue hemorrhagic fever incidence in indonesia over the past 50 years. Department of health and human services centers for. Dengue feverdengue hemorrhagic fever dengue feverdengue hemorrhagic fever bruce r. The symptoms of typical dengue fever are controllable and manageable. On 6 september 2016 the vectorborne diseases vbd team of who myanmar convened a technical workshop to develop the national clinical management guidelines for dengue and dengue hemorrhagic fever dhf, in support of myanmar health authorities and with the collaboration of experts and academics from the universities of medicines of the country. Dengue fever is a selflimited acute illness that lasts for 2 to 7 days and includes fever, rash, myalgia, and arthralgia. The purpose of this study is to describe the care provided in a hydration tent, including early detection, treatment, and serial followup. Description of the clinical picture of dengue hemorrhagic feverdengue shock syndrome dhfdss in adults. The global prevalence of dengue cases has increased in southeast asia.
Dengue chapter 4 2020 yellow book travelers health cdc. To view the erratum, please click here dengue fever is a mosquitotransmitted disease caused by any of four closely related virus serotypes den1, den2, den3, and den4 of the genus flavivirus. Severe dengue is called dengue hemorrhagic fever dhf and dates back to the 1950s. Dengue fever df is the most prevalent mosquitoborne viral illness in the world endemic in more than 100 countries, with 2. Dengue diagnosis, advances and challenges sciencedirect. Dengue hemorrhagic fever and dengue shock syndrome some patients with dengue fever go on to develop dengue hemorrhagic fever dhf, a severe and sometimes fatal form of the disease. Louis encephalitis virus, japanese encephalitis virus, tickborne encephalitis virus, kyasanur forest disease virus, and omsk hemorrhagic fever virus. Guidelines for dengue hemorrhagic fever case management. Dengue is caused by four different strains of virus. There are several mosquitoes in the tropic areas that are carriers of the dengue virus and this mosquito can also be infected if it bites any person who has dengue virus in his blood.
Dengue fever is common in tropical areas, so take extra precautions if you travel somewhere with this type of. Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever vii dengue fever is the fastest emerging arboviral infection spread by aedes mosquitoes with major public health consequences in over 100 tropical and subtropical countries in southeast asia, the western pacific and south and central america. Most adults were positive for symptoms like fever, myalgia, arthralgia, and skin rash and bleeding. Finally, dengue diagnosis is of major importance for research into host, virus and vector characteristics. Graham in 1903 implicated aedes aegypti as the vector for the disease and the virus was isolated in 1944 by albert sabin et al1. A second exposure to the virus can result in dengue hemorrhagic fever, a.
In this case report, we will discuss the pathophysiology and management of severe dengue hemorrhagic fever and bleeding complications in an intensive care unit icu. Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever iv. These viruses are related to the viruses that cause the west nile infection and yellow fever. Dengue virus infection causes dengue fever df, dengue hemorrhagic fever. Developing guidelines for the clinical management of. Dengue is commonly confused with other infectious illnesses such as influenza, measles, malaria, typhoid, and scarlet fever.
The viruses that cause dengue fever are related to those that. Read more about symptoms, diagnosis, treatment, complications, causes and prognosis. Dengue is a potentially fatal acute febrile illness caused by infection with any of four dengue viruses denv1, 2, 3, and 4. Clinical study of diagnosed cases of dengue fever in tertiary care. A risk factor for dengue hemorrhagic fever request pdf. Dengue fever and dengue haemorrhagic fever the lancet. Dengue fever is a virus transmitted to humans through bites from the aedes mosquito, a daybiting mosquito. Clinical manifestations and management of denguedhfdss ncbi. Dengue fever, a very old disease, has reemerged in the past 20 years with an expanded geographic distribution of both the viruses and the mosquito vectors, increased epidemic activity, the development of hyperendemicity the cocirculation of multiple serotypes, and the emergence of dengue hemorrhagic fever in new geographic regions. A second exposure to the virus can result in dengue hemorrhagic fever, a lifethreatening illness. In the first four days after onset of fever, either rtpcr or virus isolation are the recommended assays for confirmation of dengue infection 30.
The patient should be taken to the hospital as soon as experience these. Dengue hemorrhagic fever is a fatal manifestation of dengue virus that manifest with bleeding diathesis and hypovolemic shock. Dengue is a mosquitoborne disease caused by any one of four closely related dengue. Dengue hemorrhagic fever can occur when someone is bitten by a mosquito or exposed to blood infected with the dengue virus.
Jun 28, 2019 people with weakened immune systems as well as those with a second or subsequent dengue infection are believed to be at greater risk for developing dengue hemorrhagic fever. Why only some people develop lifethreatening dengue infections. When a person is infected with dengue virus for the first. The increasingly widespread distribution and the rising incidence of dengue virus infections are related to increased. Denv serotypes can be further classified into different. Dengue fever is also known as backbone fever and the virus cannot be directly transmitted from one person to another. Transmission almost all transmission occurs through the bite of infected aedes mosquitoes, primarily. Diagnosis of dengue infection during pregnancy surely affects management options and decisions as the mode and time of delivery are of utmost importance. An outbreak took place in the philippines and thailand but is now more prominent in the countries of asia and latin america, where it is one of the main contributors to hospitalization and death.
High fever for 2 7 days, similar to mild form of dengue infection. To view the erratum, please click here dengue fever is a mosquitotransmitted disease caused by any of four closely related virus serotypes den1. Gubler d engue and dengue hemorrhagic fever dhf are caused by infection with dengue viruses. Management of severe dengue hemorrhagic fever and bleeding. Dengue fever is a disease spread by the aedes aegypti mosquito and caused by one of four dengue viruses that are closely related. The global prevalence of dengue cases has increased in southeast asia, africa, the western pacific, and the americas. Dengue is a mosquitoborne seasonal viral infection, caused by four closely related viruses denv 14. Dhf starts abruptly with high continuous fever and headache plus respiratory and intestinal symptoms with sore throat, cough, nausea, vomiting, and abdominal pain. Early detection of the disease, followed by intravenous fluid therapy in patients with dengue hemorrhagic fever dhf or with warning signs of dengue has a major impact on the prognosis. According to the virus virulence hypothesis, certain denv strains are responsible for more severe disease. Transmission almost all transmission occurs through the bite of infected aedes mosquitoes, primarily aedes aegypti and ae.
How to cure dengue fever the solution and best home. Disease burden of dengue fever and dengue haemorrhagic fever 3. After fever reduces, patient develops severe vomiting and abdominal pain with breathing difficulty. Dengue hemorrhagic fever is an acute infectious disease caused by dengue virus. It gets transmitted by the bite of the female mosquito of genus aedes. Who is at greater risk for developing dengue hemorrhagic fever. Dec 07, 2018 dengue is also known as breakbone fever, hemorrhagic fever, dandy fever, infectious thrombocytopenic purpura. Kalayanarooj s, vaughn dw, nimmannitya s, green s, suntayakorn s, kunentrasai n, viramitrachai w, ratanachueke s. These symptoms could indicate a progression to dengue hemorrhagic fever, the severest form of the disease, with fatality rates as high as 20 percent. Most dengue virus infections are asymptomatic, but some patients may develop either dengue fever or the more severe dengue hemorrhagic fever. Management of dengue fever and dengue hemorrhagic fever slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. It is a vasculopathy that consists in endothelial lesions which allow plasma leakage and hemorrhages. Infection with one of these serotypes does not provide crossprotective immunity, so persons living in a dengueendemic area can have four dengue infections during their lifetimes.
Dengue hemorrhagic fever may arise from repeated infection with different serotypes of the dengue virus. Other members of the same genus include yellow fever virus, west nile virus, zika virus, st. As both cell tropism and tissue tropism of denv are considered major determinants in the pathogenesis of dengue, there is a critical need for adequate tropism. Infection with one of these serotypes does not provide crossprotective immunity, so persons living in a dengue endemic area can have four dengue infections. Dengue fever does not need to be fatal, if the patient is able to access proper medical care, or is able to source good homebased preventive care. Otherwise it has proposed the following classification. These viruses are related closely to each other antigenically, and, as a result, serological tests reflect extensive crossreactivity. Dengue and dengue hemorrhagic fever dhf are caused by one of four closely related, but antigenically distinct, virus serotypes den1, den2, den3, and den4, of the genus flavivirus.
We described the highresolution ct findings in a 70yearold male with the disease, which was diagnosed by clinical examination and confirmed by serological methods. Jan 17, 2016 dengue and dengue hemorrhagic fever 1. However, disease caused by dengue virus infection is classified into two clinical entities. Fever that lasts from 2 to 7 days with general signs and symptoms of nausea, vomiting, abdominal pain and headache, followed by hemorrhagic. More severe forms of the disease, dengue hemorrhagic fever or dengue shock syndrome are very rare among travelers. Dengue fever virus denv is an rna virus of the family flaviviridae.
Duane j gubler, dukenus graduate medical school, singapore, eng eong ooi, dukenus graduate medical school, singapore, goro kuno, arboviral disease branch, centers for disease control and prevention, subhash vasudevan, dukenus graduate medical school, singapore, jeremy farrar, wellcome trust, uk. Pdf we report a case of imported dengue hemorrhagic fever dhf in a 10year old philippine boy. There is a need for laboratory confirmation if technology exists. In their case report about a tourist with dengue fever and visual loss, christos haritoglou and colleagues oct 5, p 10701 state that there are four stages of dengue fever. The who deems it not appropriate to adopt a detailed clinical definition of dengue fever because of the variability in the clinical illness associated with dengue infection. Treatment includes rehydration and recovery is expected. The early prediction of severe dengue in patients without any warning signs who may later develop severe dhf is very important to choose. Around the time the fever begins to subside usually 37 days after symptom onset, the patient may develop warning signs of severe disease.
The causative agent of denfue hemorrhagic fever dhf is dengue virus, of which there are 4 serotypes. The illness may last up to 10 days, but complete recovery can take 2 to 4 weeks. Immunopathogenesis of dengue virus infection springerlink. The aedes aegypti mosquito is mostly found in tropical areas including subcontinent, pakistan, africa and latin.
Clinical and serologic study of cuban children with dengue hemorrhagic feverdengue shock syndrome dhfdss. Dengue and dengue hemorrhagic fever linkedin slideshare. Most dengue virus infections in adults are symptomatic. Dengue is a major public health problem worldwide, where an estimated 400 million denv infections and 100 million clinically apparent dengue cases occurred in 2010. Pdf risk factors for hemorrhage in severe dengue infections. Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever df, or severe forms, such as dengue hemorrhagic fever dhf and dengue shock syndrome dss in affected individuals. Esse video devidamente registrado, esta a venda juntamen. Dengue, an acute febrile illness, is caused by infection with any of 4 related positivesense, singlestranded rna viruses of the genus flavivirus, dengue viruses 1, 2, 3, or 4. Dengue fever and dengue hemorrhagic fever are reemerging diseases that are endemic in the tropics. Dss3,4caused by infection with dengue virus, is not a new disease, but. Viral hemorrhagic fever dengue fever presented by jega subramaniam, student guided by ap. We propose a new hypothesis for the immunopathogenesis for dengue virus.
Typical clinical manifestations of dengue range from selflimited dengue fever df to dengue hemorrhagic fever with shock syndrome. Aug 25, 2019 dengue fever, or west nile fever, is a mild viral illness transmitted by mosquitoes which causes fever, rashes and muscle and joint aches. Opinion 10 days of dengue fever the new york times. If you continue browsing the site, you agree to the use of cookies on this website. Dengue fever is caused by virus that is transmitted when a specific type of mosquito bites humans. Fatality is a distinct possibility only if the fever graduates to a more serious condition called the dengue hemorrhagic fever dhf. Dengue fever dengue hemorrhagic fever dengue fever dengue hemorrhagic fever bruce r. Dengue fever, or west nile fever, is a mild viral illness transmitted by mosquitoes which causes fever, rashes and muscle and joint aches. In contrast, most infections among children under age 15 years are asymptomatic or minimally symptomatic. Epidemiology of dengue hemorrhagic fever in indonesia. A syndrome due to the dengue virus that tends to affect children under 10, causing abdominal pain, hemorrhage bleeding and circulatory collapse.
Technical guides for diagnosis, treatment, surveillance, prevention and control of dengue haemorrhagic fever. Dengue hemorrhagic fever dhf dhf is a severe form of dengue infection. Pdf we report a case of imported dengue hemorrhagic fever dhf in a 10yearold philippine boy. To provide a national incidence rate and case fatality rate of dengue hemorrhagic fever in indonesia through an analysis of the national disease surveillance database from the directorate general of disease prevention and control of ministry of health. Yoshiki kusama at national center for global health and medicine hospital. Highresolution ct demonstrated bilateral areas of consolidation with air bronchogram and ground glass opacities, as well as small bilateral. These viruses are related closely to each other antigenically, and, as. When a person is infected with dengue virus for the first time, clinical signs and symptoms are usually mild. Dengue fever is one of the most common tropical diseases worldwide. Known also as dengue hemorrhagic fever dhf, it starts abruptly with high continuous fever and headache plus respiratory and intestinal symptoms with sore throat.
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